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KMID : 0882420080750050539
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Korean Journal of Medicine
2008 Volume.75 No. 5 p.539 ~ p.545
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Prevalence of occult HBV infection in alcholic and non-alcoholic subjects lacking the hepatitis B surface antigen
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Oh Sung-Nam
Yeon Jong-Eun
Han Woo-Sik
Choi Do-Won
Kim Ji-Hyun
Kim Yeoun-Ho
Park Jong-Jae
Kim Jae-Seon
Byun Kwan-Soo
Park Young-Tae
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Abstract
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Backgrounds/Aims: Hepatitis B virus (HBV) infection and chronic alcoholism are major risk factors for chronic liver disease in Korea.
Methods: We investigated the prevalence of occult HBV infection in 198 non-alcoholic (group I) and 85 chronic
alcoholic subjects (group II), none of whom showed the hepatitis B surface antigen (HBsAg). Among chronic alcoholics,
25 patients showed cirrhosis. Using serum samples stored at -70℃, liver enzymes, anti-Hbs, and IgG anti-HBc were
measured via EIA and serum HBV DNA was quantified via real time PCR.
Results: IgG anti-HBc seropositivity, an indicator of past infection, was higher in group II (64.7%) than in group I
(43.4%; p<0.01). Eleven of 283 patients (3.2%) were seropositive for HBV DNA, indicating occult infection, but this value
did not differ between groups (group I: 3.5%, 7/198; group II: 4.7%, 4/85; p=0.64). In group II, HBV DNA seropositivity
was higher in cirrhotic patients (12%, 3/25) than in non-cirrhotic alcoholic liver disease (1.7%, 1/60; p=0.074).
Conclusions: Past HBV infection was more prevalent in alcoholics than non-alcoholics, but the prevalence of occult HBV infection did not differ between groups. However, alcoholics with cirrhosis tended to show a higher prevalence of occult HBV infection.
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KEYWORD
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Alcoholism, Hepatitis B virus, Occult infection
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